Citation: Hai Shen Yang, Xiao Xiao Qiao, Qing Cui, Xiao Hua Xu. First synthesis of (±)-cedarmycin B[J]. Chinese Chemical Letters, ;2009, 20(9): 1023-1025. doi: 10.1016/j.cclet.2009.04.029 shu

First synthesis of (±)-cedarmycin B

State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Received Date: 13 February 2009

Fund Project: We thank the National Science Foundation of China (Nos.20421202, 20572055) for financial support.

The synthesis of racemic cedarmycin B, an antibiotic from Streptomyces sp. TP-A0456 was achieved firstly from γ-butyrolactone.The key step was a Barbier-type addition of 3-bromomethyl-5H-furan-2-one to formaldehyde mediated by zinc,which afforded the sole g-addition product 4-hydroxymethyl-3-methylene-dihydrofuran-2-one. The final compound was confirmed by ¹H NMR,₁₃C NMR and HRMS.
- Cedarmycin B,
- Antibiotic,
- Streptomyces sp.,
- Barbier reaction
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