引用本文:
Xin Zhai, Nan Jiang, Ke Liang Zhang, Feng Bao, Ping Gong. Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo[1,5-a]pyrimidines[J]. Chinese Chemical Letters,
2009, 20(10): 1179-1182.
doi:
10.1016/j.cclet.2009.04.027
Citation: Xin Zhai, Nan Jiang, Ke Liang Zhang, Feng Bao, Ping Gong. Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo[1,5-a]pyrimidines[J]. Chinese Chemical Letters, 2009, 20(10): 1179-1182. doi: 10.1016/j.cclet.2009.04.027
Citation: Xin Zhai, Nan Jiang, Ke Liang Zhang, Feng Bao, Ping Gong. Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo[1,5-a]pyrimidines[J]. Chinese Chemical Letters, 2009, 20(10): 1179-1182. doi: 10.1016/j.cclet.2009.04.027
Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo[1,5-a]pyrimidines
摘要:
In our efforts to identify novel potent anticancer agents, we synthesized a series of 2,7-disubstituted triazolo[1,5-a]pyrimidines (6-16).Their antiproliferative activity against Bel-7402, HT-1080 and WI-38 cell lines was tested by MTTassay in vitro.Four of the compounds (9-11 and 16) displayed promising antiproliferative activity superior to gefitinib, especially compound 9.A preliminary SAR study of these derivatives was performed.
English
Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo[1,5-a]pyrimidines
Abstract:
In our efforts to identify novel potent anticancer agents, we synthesized a series of 2,7-disubstituted triazolo[1,5-a]pyrimidines (6-16).Their antiproliferative activity against Bel-7402, HT-1080 and WI-38 cell lines was tested by MTTassay in vitro.Four of the compounds (9-11 and 16) displayed promising antiproliferative activity superior to gefitinib, especially compound 9.A preliminary SAR study of these derivatives was performed.
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Key words:
- Triazolo[1,5-a]pyrimidines
- / Synthesis
- / Antiproliferative activity
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