引用本文:
Xue Sen Fan Xia Wang, Xin Ying Zhang, Dong Feng, Ying Ying Qu. Preparation of nucleoside-pyridine hybrids and pyridine attached acylureas from an unexpected uracil ring-opening and pyridine ring-forming sequence[J]. Chinese Chemical Letters,
2009, 20(10): 1161-1165.
doi:
10.1016/j.cclet.2009.04.014
Citation: Xue Sen Fan Xia Wang, Xin Ying Zhang, Dong Feng, Ying Ying Qu. Preparation of nucleoside-pyridine hybrids and pyridine attached acylureas from an unexpected uracil ring-opening and pyridine ring-forming sequence[J]. Chinese Chemical Letters, 2009, 20(10): 1161-1165. doi: 10.1016/j.cclet.2009.04.014
Citation: Xue Sen Fan Xia Wang, Xin Ying Zhang, Dong Feng, Ying Ying Qu. Preparation of nucleoside-pyridine hybrids and pyridine attached acylureas from an unexpected uracil ring-opening and pyridine ring-forming sequence[J]. Chinese Chemical Letters, 2009, 20(10): 1161-1165. doi: 10.1016/j.cclet.2009.04.014
Preparation of nucleoside-pyridine hybrids and pyridine attached acylureas from an unexpected uracil ring-opening and pyridine ring-forming sequence
摘要:
Novel pyrimidine nucleoside-3,5-dicyanopyridine hybrids (4) or pyridine attached acylureas (5) were selectively and efficiently prepared from the reaction of 2'-deoxyuridin-5-yl-methylene malononitrile (1), malononitrile (2) and thiophenol (3) or from an unexpected uracil ring-opening and pyridine ring-forming sequence via the reaction of 1 and 3.It is the first time such a sequence has ever been reported.
English
Preparation of nucleoside-pyridine hybrids and pyridine attached acylureas from an unexpected uracil ring-opening and pyridine ring-forming sequence
Abstract:
Novel pyrimidine nucleoside-3,5-dicyanopyridine hybrids (4) or pyridine attached acylureas (5) were selectively and efficiently prepared from the reaction of 2'-deoxyuridin-5-yl-methylene malononitrile (1), malononitrile (2) and thiophenol (3) or from an unexpected uracil ring-opening and pyridine ring-forming sequence via the reaction of 1 and 3.It is the first time such a sequence has ever been reported.
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Key words:
- Pyrimidine nucleoside
- / Pyridine
- / Acylureas
- / Ring-opening and -forming reaction
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