Citation: Feng Xiao, Yadong Xue, Yu Luo, Bo Zhang, Wei Lu, Bo Yang. Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives[J]. Chinese Chemical Letters, ;2009, 20(5): 566-568. doi: 10.1016/j.cclet.2008.12.019 shu

Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives

Feng Xiao ^a, ,
Yadong Xue ^a ,
Yu Luo ^a ,
Bo Zhang ^b ,
Wei Lu ^a ,
Bo Yang ^b

a Department of Chemistry, East China Normal University, Shanghai 200062, PR China;
b School of Pharmaceutical Science, Zhejiang University, Hangzhou 310007, PR China

Received Date: 17 October 2008

Several 7-alkynyl camptothecin derivatives were prepared via Sonogashira coupling. And anti-tumor activities of these compounds were evaluated against human esophageal cancer cell line (Eca-109), human chronic myeloid leukaemia cell line (K562), bladder cancer cell line (5637) and gastric cell line (SGC7901). Compounds 9a-d and 10a exhibited remarkable in vitro cytotoxic activity, compared with topotecan.
- Camptothecin,
- Anticancer,
- Synthesis
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