Citation: Wei Fan, Lei Chen, Li Hai, Yong Wu. New method in synthesizing an optical active intermediate for (R,R)-formoterol[J]. Chinese Chemical Letters, ;2008, 19(3): 279-280. doi: 10.1016/j.cclet.2008.01.012 shu

New method in synthesizing an optical active intermediate for (R,R)-formoterol

Key Laboratory of Drug Targeting Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Received Date: 23 October 2007

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 29972013).

(R)-1-(4-Methoxyphenyl) propan-2-amine 2a, an optical active intermediate for (R,R)-formoterol, was synthesized from D-alanine in 65% overall yield by using a simple route, which contained protecting amino group, cyclization, coupling with Grignard reagent, reduction and deprotection.
- (R)-1-(4-Methoxyphenyl)propan-2-amine,
- Formoterol,
- Intermediate,
- Synthesis
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