Citation: Qin Zhang, Yao Fu, Hao Wei Wang, Tao Gong, Yong Qin, Zhi Rong Zhang. Synthesis and cytotoxic activity of novel curcumin analogues[J]. Chinese Chemical Letters, ;2008, 19(3): 281-285. doi: 10.1016/j.cclet.2007.12.035 shu

Synthesis and cytotoxic activity of novel curcumin analogues

Key Laboratory of Drug Targeting Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Received Date: 29 October 2007

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 30600786).

Five novel curcumin analogues bearing different substituents at 4-position of phenyl group were synthesized. Their structures were confirmed by NMR and HRMS spectrum. Their cytotoxic activities against six tumor cell lines were tested by the standard MTT assay in vitro. The results indicated that four analogues (1A-1C, 1E) with solubilizing moieties showed selective potent cytotoxicity against HepG2, HeLa and CT26 cell lines, and analogue 1A and 1C exhibited more potent cytotoxicity than curcumin against CT26 cell line. It was suggested that introduction of appropriate substituents to 4-position of phenyl group might be a potential option for structural modification of curcumin.
- Curcumin analogues,
- Synthesis,
- Cytotoxic activity,
- Anti-tumor activity
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