引用本文:
Qing Lin Jiang, Li Hai, Lei Chen, Jiao Lu, Zhi Rong Zhang, Yong Wu. Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery[J]. Chinese Chemical Letters,
2008, 19(2): 127-129.
doi:
10.1016/j.cclet.2007.12.002
Citation: Qing Lin Jiang, Li Hai, Lei Chen, Jiao Lu, Zhi Rong Zhang, Yong Wu. Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery[J]. Chinese Chemical Letters, 2008, 19(2): 127-129. doi: 10.1016/j.cclet.2007.12.002
Citation: Qing Lin Jiang, Li Hai, Lei Chen, Jiao Lu, Zhi Rong Zhang, Yong Wu. Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery[J]. Chinese Chemical Letters, 2008, 19(2): 127-129. doi: 10.1016/j.cclet.2007.12.002
Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery
摘要:
A novel bifunctional glycolipid which carried a cluster of thiogalactosides as the bepatocyte targeting ligand for gene delivery was prepared.Hexa-antennary alcohol 1 was used as the core scaffold to attach a cholesterol molecule by a poly (ethylene glycol) chain, while its remaining branches were linked with five acetylgalactosides, which would be deacetylated later to produce pentaantennary galaetoside.Liposome containing the galactoside showed high affinity and transfection activity in hepatoma cells HepG2.
English
Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery
Abstract:
A novel bifunctional glycolipid which carried a cluster of thiogalactosides as the bepatocyte targeting ligand for gene delivery was prepared.Hexa-antennary alcohol 1 was used as the core scaffold to attach a cholesterol molecule by a poly (ethylene glycol) chain, while its remaining branches were linked with five acetylgalactosides, which would be deacetylated later to produce pentaantennary galaetoside.Liposome containing the galactoside showed high affinity and transfection activity in hepatoma cells HepG2.
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Key words:
- Clustered glycosides
- / Targeting
- / Galactosylated ligand
- / Hepatocyte
- / Gene delivery
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