Citation: Zhen Li Min, Yi Hua Zhang, Yi Sheng Lai, Si Xun Peng. Asymmetric synthesis of 3-butylphthalide using isomannide and isosorbide as chiral auxiliaries[J]. Chinese Chemical Letters, ;2007, 18(11): 1361-1363. doi: 10.1016/j.cclet.2007.09.038 shu

Asymmetric synthesis of 3-butylphthalide using isomannide and isosorbide as chiral auxiliaries

Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China

Received Date: 23 July 2007

A new approach for asymmetric syntheses of (S) and (R)-3-n-butylphthalide (NBP) is presented. The diastereoselective addition of dibutylzinic to aromatic aldehyde 10 or 11 generated from isomannide-or isosorbide-derived chiral auxiliary afforded S-NBP or R-NBP in high optical yields.
- Asymmetric synthesis,
- 3-n-Butylphthalide,
- Isomannide,
- Isosorbide
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