Citation: Geng Xu, Zhan Zhu Liu, Jing Hua Yang, Shi Zhi Chen, Hui Ying Yang. Stereoselective synthesis of 3-butylphtalide via CBS catalytic reduction[J]. Chinese Chemical Letters, ;2007, 18(6): 653-655. doi: 10.1016/j.cclet.2007.04.040 shu

Stereoselective synthesis of 3-butylphtalide via CBS catalytic reduction

a Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100050, China;
b National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China

Optically active 3-butylphtalide of high enantiomeric excesses (up to 93% e.e.) was synthesized from the reduction of o-pentanoylbenzoic ester with borane using B-methyloxyoxazaborolidine (1b) as the chiral catalyst.
- Stereoselective synthesis,
- 3-Butylphtalide,
- CBS catalytic reduction,
- o-Pentanoylbenzoic ester
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