Citation: Yan Zhang, Zi-Peng Yuan, Yu Qin, Ji Dai, Tao Zhang. Comparative Studies on Hydrophilic and Hydrophobic Segments Grafted Poly(vinyl chloride)[J]. Chinese Journal of Polymer Science, ;2018, 36(5): 604-611. doi: 10.1007/s10118-018-2034-x shu

Comparative Studies on Hydrophilic and Hydrophobic Segments Grafted Poly(vinyl chloride)

Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China

Corresponding author: Tao Zhang, ztnj@nju.edu.cn
Received Date: 2 August 2017
Accepted Date: 5 September 2017
Available Online: 18 January 2018

Poly(vinyl chloride) (PVC) is one of the mostly produced plastics in the world and is widely used in single-use medical devices. However, the additives that are often necessary for PVC arouse concerns of its safety, thus quests the modifications of PVC itself. In this study, poly(ethylene glycol) (PEG) and polydimethylsiloxane (PDMS) segments were grafted onto PVC backbone in similar ways, and the chemical structures of the modified PVCs were characterized by Fourier transform infrared spectra, X-ray photoelectron spectra, thermogravimetric analysis and differential scanning calorimetry. Moreover, the water contact angle, protein adsorption, platelet adhesion, cell attachment and proliferation on different material surfaces were studied and compared. It was found that both PEG and PDMS grafting yielded improvement on biocompatibility compared with bare PVC, while hydrophobic PDMS grafted PVC showed more effective on cell attachment and proliferation than that of hydrophilic PEG grafted PVC.
- Poly(vinyl chloride),
- Poly(ethylene glycol),
- Polydimethylsiloxane,
- Grafting,
- Biomedical properties
1. [1]
  Allsopp, M. W. ; Vianello, G., "Poly(vinyl chloride)" in "Ullmann's encyclopedia of industrial chemistry, 7^th Ed. "; ed. by Elvers, B., John Wiley & Sons, New York, 2014.
2. [2]
  Blass, C. R., in "The role of poly(vinyl chloride) in healthcare"; Rapra Technology Limited, Shrewsbury, UK, 2001.
3. [3]
  PVCMed Alliance, in "PVC medical devices", http://pvcmed.org/pvc-in-healthcare/pvc-medical-devices/, available on Feb. 11, 2017.
4. [4]
  Lakshmi S., Jayakrishnan A.. Migration resistant, blood-compatible plasticized polyvinyl chloride for medical and related applications[J]. Artif. Organs, 1998,22(3):222-229. doi: 10.1046/j.1525-1594.1998.06124.x
5. [5]
  Scientific Committee on Emerging and Newly-Identified Health Risks (SCENIHR), Scientific opinion on the safety of medical devices containing DEHP-plasticized PVC or other plasticizers on neonates and other groups possibly at risk. European Commission, Brussels, 2008.
6. [6]
  Ferruti P., Barbucci R., Danzo N., Torrisi A., Puglisi O., Pignataro S., Spartano P.. Preparation and ESCA characterization of poly(vinyl chloride) surface-grafted with heparin-complexing poly(amido-amine) chains[J]. Biomaterials, 1982,3(1):33-37. doi: 10.1016/0142-9612(82)90058-8
7. [7]
  Singh J., Ray A. R., Singhal J. P., Singh H.. Radiation-induced graft copolymerization of methacrylic acid on to poly(vinyl chloride) films and their thrombogenicity[J]. Biomaterials, 1990,11(7):473-476. doi: 10.1016/0142-9612(90)90060-4
8. [8]
  Ji J., Feng L., Shen J., Barbosa M. A.. Preparation of albumin preferential surfaces on poly(vinyl chloride) membranes via surface self-segregation[J]. J. Biomed. Mater. Res., 2002,61(2):252-295. doi: 10.1002/(ISSN)1097-4636
9. [9]
  Balakrishnan B., Kumar D. S., Yoshida Y., Jayakrishnan A.. Chemical modification of poly(vinyl chloride) resin using poly(ethylene glycol) to improve blood compatibility[J]. Biomaterials, 2005,26(17):3495-3502. doi: 10.1016/j.biomaterials.2004.09.032
10. [10]
  Asadinezhad A., Novak I., Lehocky M., Bilek F., Vesel A., Junkar I., Saha P., Popelka A.. Polysaccharides coatings on medical-grade PVC:a probe into surface characteristics and the extent of bacterial adhesion[J]. Molecules, 2010,15(2):1007-1027. doi: 10.3390/molecules15021007
11. [11]
  Bigot S., Louarn G., Kebir N., Burel F.. Click grafting of seaweed polysaccharides onto PVC surfaces using an ionic liquid as solvent and catalyst[J]. Carbohyd. Polym., 2013,98(2):1644-1649. doi: 10.1016/j.carbpol.2013.07.079
12. [12]
  Neffe A. T., von Ruesten-Lange M., Braune S., Luetzow K., Roch T., Richau K., Jung F., Lendlein A.. Poly(ethylene glycol) grafting to poly(ether imide) membranes:influence on protein adsorption and thrombocyte adhesion[J]. Macromol. Biosci., 2013,13(12):1720-1729. doi: 10.1002/mabi.201300309
13. [13]
  Patel R., Patel M., Ahn S. H., Sung Y. K., Lee H. K., Kim J. H., Sung J. S.. Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers[J]. Mat. Sci. Eng. Mater., 2013,33(3):1662-1670. doi: 10.1016/j.msec.2012.12.097
14. [14]
  Dabagh M., Abdekhodaie M. J., Khorasani M. T.. Effects of polydimethylsiloxane grafting on the calcification, physical properties, and biocompatibility of polyurethane in a heart valve[J]. J. Appl. Polym. Sci., 2005,98(2):758-766. doi: 10.1002/(ISSN)1097-4628
15. [15]
  Lakshmi, Jayakrishnan, A. Synthesis, surface properties and performance of thiosulphate-substituted plasticized poly(vinyl chloride)[J]. Biomaterials, 2002,23(24):4855-4862. doi: 10.1016/S0142-9612(02)00243-0
16. [16]
  Kainthan R. K., Gnanamani M., Ganguli M., Ghosh T., Brooks D. E., Maiti S., Kizhakkedathu J. N.. Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA[J]. Biomaterials, 2006,27(31):5377-5390. doi: 10.1016/j.biomaterials.2006.06.021
17. [17]
  Gorbet M. B., Sefton M. V.. Biomaterial-associated thrombosis:roles of coagulation factors, complement, platelets and leukocytes[J]. Biomaterials, 2004,25(26):5681-5703. doi: 10.1016/j.biomaterials.2004.01.023
1. [1]
  Xinyu Liu , Jialin Yang , Zonglin He , Jiaoyan Ai , Lina Song , Baohua Liu . Linear polyurethanes with excellent comprehensive properties from poly(ethylene carbonate) diol. Chinese Chemical Letters, 2025, 36(1): 110236-. doi: 10.1016/j.cclet.2024.110236
2. [2]
  Haojie Song , Laiyu Luo , Siyu Wang , Guo Zhang , Baojiang Jiang . Advances in poly(heptazine imide)/poly(triazine imide) photocatalyst. Chinese Chemical Letters, 2024, 35(10): 109347-. doi: 10.1016/j.cclet.2023.109347
3. [3]
  Chong Liu , Ling Li , Jiahui Gao , Yanwei Li , Nazhen Zhang , Jing Zang , Cong Liu , Zhaopei Guo , Yanhui Li , Huayu Tian . The study of antibacterial activity of cationic poly(β-amino ester) regulating by amphiphilic balance. Chinese Chemical Letters, 2025, 36(2): 110118-. doi: 10.1016/j.cclet.2024.110118
4. [4]
  Xiaoxiao Huang , Zhi-Long He , Yangpeng Chen , Lei Li , Zhenyu Yang , Chunyang Zhai , Mingshan Zhu . Novel P-doping-tuned Pd nanoflowers/S,N-GQDs photo-electrocatalyst for high-efficient ethylene glycol oxidation. Chinese Chemical Letters, 2024, 35(6): 109271-. doi: 10.1016/j.cclet.2023.109271
5. [5]
  Jie Wu , Xiaoqing Yu , Guoxing Li , Su Chen . Engineering particles towards 3D supraballs-based passive cooling via grafting CDs onto colloidal photonic crystals. Chinese Chemical Letters, 2024, 35(4): 109234-. doi: 10.1016/j.cclet.2023.109234
6. [6]
  Weijian Zhang , Xianyu Deng , Liying Wang , Jian Wang , Xiuting Guo , Lianggui Huang , Xinyi Wang , Jun Wu , Linjia Jiang . Poly(ferulic acid) nanocarrier enhances chemotherapy sensitivity of acute myeloid leukemia by selectively targeting inflammatory macrophages. Chinese Chemical Letters, 2024, 35(9): 109422-. doi: 10.1016/j.cclet.2023.109422
7. [7]
  Chen Lian , Si-Han Zhao , Hai-Lou Li , Xinhua Cao . A giant Ce-containing poly(tungstobismuthate): Synthesis, structure and catalytic performance for the decontamination of a sulfur mustard simulant. Chinese Chemical Letters, 2024, 35(10): 109343-. doi: 10.1016/j.cclet.2023.109343
8. [8]
  Mengyuan Li , Xitong Ren , Yanmei Gao , Mengyao Mu , Shiping Zhu , Shufang Tian , Minghua Lu . Constructing bifunctional magnetic porous poly(divinylbenzene) polymer for high-efficient removal and sensitive detection of bisphenols. Chinese Chemical Letters, 2024, 35(12): 109699-. doi: 10.1016/j.cclet.2024.109699
9. [9]
  Haibo Ye , Qianyu Li , Juan Li , Didi Li , Zhimin Ao . Review on the abiotic degradation of biodegradable plastic poly(butylene adipate-terephthalate): Mechanisms and main factors of the degradation. Chinese Chemical Letters, 2025, 36(1): 109861-. doi: 10.1016/j.cclet.2024.109861
10. [10]
  Yaxuan Jin , Chao Zhang , Guigang Zhang . Atomically dispersed low-valent Au on poly(heptazine imide) boosts photocatalytic hydroxyl radical production. Chinese Journal of Structural Chemistry, 2024, 43(12): 100414-100414. doi: 10.1016/j.cjsc.2024.100414
11. [11]
  Shuxin Liu , Jinjuan Ma , Aiguo Wang , Nan Zheng . Decomposable and sono-enzyme co-triggered poly(sonosensitizers) for precise and hypotoxic sonodynamic therapy. Chinese Chemical Letters, 2025, 36(4): 110032-. doi: 10.1016/j.cclet.2024.110032
12. [12]
  Zhili Li , Qijun Wo , Dongdong Huang , Dezhong Zhou , Lei Guo , Yeqing Mao . Improving gene transfection efficiency of highly branched poly(β-amino ester)s through the in-situ conversion of inactive terminal groups. Chinese Chemical Letters, 2024, 35(8): 109737-. doi: 10.1016/j.cclet.2024.109737
13. [13]
  Tong Tong , Lezong Chen , Siying Wu , Zhong Cao , Yuanbin Song , Jun Wu . Establishment of a leucine-based poly(ester amide)s library with self-anticancer effect as nano-drug carrier for colorectal cancer treatment. Chinese Chemical Letters, 2024, 35(12): 109689-. doi: 10.1016/j.cclet.2024.109689
14. [14]
  Zhenchun Yang , Bixiao Guo , Zhenyu Hu , Kun Wang , Jiahao Cui , Lina Li , Chun Hu , Yubao Zhao . Molecular engineering towards dual surface local polarization sites on poly(heptazine imide) framework for boosting H₂O₂ photo-production. Chinese Chemical Letters, 2024, 35(8): 109251-. doi: 10.1016/j.cclet.2023.109251
15. [15]
  Binhan Zhao , Zheng Li , Lan Zheng , Zhichao Ye , Yuyang Yuan , Shanshan Zhang , Bo Liang , Tianyu Li . Recent progress in the biomedical application of PEDOT:PSS hydrogels. Chinese Chemical Letters, 2024, 35(10): 109810-. doi: 10.1016/j.cclet.2024.109810
16. [16]
  Manoj Kumar Sarangi , L․D Patel , Goutam Rath , Sitansu Sekhar Nanda , Dong Kee Yi . Metal organic framework modulated nanozymes tailored with their biomedical approaches. Chinese Chemical Letters, 2024, 35(11): 109381-. doi: 10.1016/j.cclet.2023.109381
17. [17]
  Hongyi Li , Huiyun Wen , He Zhang , Jin Li , Xiang Cao , Jiaqing Zhang , Yutao Zheng , Saipeng Huang , Weiming Xue , Xiaojun Cai . Polymeric micelle-hydrogel composites design for biomedical applications. Chinese Chemical Letters, 2025, 36(5): 110072-. doi: 10.1016/j.cclet.2024.110072
18. [18]
  Yating Zheng , Yulan Huang , Jing Luo , Xuqi Peng , Xiran Gui , Gang Liu , Yang Zhang . Supercritical fluid technology: A game-changer for biomacromolecular nanomedicine preparation and biomedical application. Chinese Chemical Letters, 2024, 35(7): 109169-. doi: 10.1016/j.cclet.2023.109169
19. [19]
  Shuaiwen Li , Zihui Chen , Feng Yang , Wanqing Yue . The age of vanadium-based nanozymes: Synthesis, catalytic mechanisms, regulation and biomedical applications. Chinese Chemical Letters, 2024, 35(4): 108793-. doi: 10.1016/j.cclet.2023.108793
20. [20]
  Kailong Zhang , Chao Zhang , Luanhui Wu , Qidong Yang , Jiadong Zhang , Guang Hu , Liang Song , Gaoran Li , Wenlong Cai . Chloride molten salt derived attapulgite with ground-breaking electrochemical performance. Chinese Chemical Letters, 2024, 35(10): 109618-. doi: 10.1016/j.cclet.2024.109618

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(902)
HTML views(66)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142