Citation: Tian-shi Feng, Hua-yu Tian, Cai-na Xu, Lin Lin, Michael Hon-Wah Lam, Hao-jun Liang, Xue-si Chen. Doxorubicin-loaded PLGA Microparticles with Internal Pores for Long-acting Release in Pulmonary Tumor Inhalation Treatment[J]. Chinese Journal of Polymer Science, ;2015, 33(7): 947-954. doi: 10.1007/s10118-015-1642-y shu

Doxorubicin-loaded PLGA Microparticles with Internal Pores for Long-acting Release in Pulmonary Tumor Inhalation Treatment

Tian-shi Feng ^1,2,3,4,5 ,
Hua-yu Tian ⁶ ,
Cai-na Xu ⁶ ,
Lin Lin ⁶ ,
Michael Hon-Wah Lam ^7,8,5 ,
Hao-jun Liang ^1,8,5 ,
Xue-si Chen ⁶

1.
1. CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China
2.
2. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3.
3. Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China
4.
4. Advanced Laboratory of Environmental Research and Technology (ALERT), Joint Advanced Research Center, USTC-City U, Suzhou 215124, China
5.
6.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
7.
1. Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China
8.
2. Advanced Laboratory of Environmental Research and Technology (ALERT), Joint Advanced Research Center, USTC-City U, Suzhou 215124, China

Received Date: 23 October 2014
Revised Date: 6 November 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 51222307, 51303173, 51390480, 21474104 and 51403205), the Ministry of Science and Technology of China (International cooperation and communication program 2011DFR51090), Jilin Province Science and Technology Development Program (Nos. 20120306, 20130521011JH).

Doxorubicin (DOX) loaded poly(lactic-co-glycolic acid) (PLGA) microparticles with internal pores (MP-D) were developed for long-acting release in pulmonary inhalation treatment. The PLGA microparticles exhibited favorable aerodynamic properties for pulmonary delivery. In vitro drug release profile suggested that MP-D have the advantage of long-term maintenance of drug concentrations. MTT assay demonstrated the in vitro anti-tumor efficiency of the DOX loaded PLGA microparticles. Furthermore, melanoma lung metastasis model was established to determine the in vivo anti-tumor efficiency. The mice treated with MP-D showed significantly fewer lesions than the untreated ones. The survival analysis indicated that MP-D prolonged the survival time of tumor-bearing mice. These results suggested that DOX loaded PLGA microparticles with internal pores have the potential to be used as long-acting release carriers in clinical lung cancer treatment.
- Doxorubicin,
- Poly(lactic-co-glycolic acid),
- Internal pores,
- Long-acting release,
- Pulmonary inhalation
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