Citation: Shu-ying Wang, Xu-dong Shi, Zhi-hua Gan, Feng Wang. Preparation of PLGA Microspheres with Different Porous Morphologies[J]. Chinese Journal of Polymer Science, ;2015, 33(1): 128-136. doi: 10.1007/s10118-014-1507-9 shu

Preparation of PLGA Microspheres with Different Porous Morphologies

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State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Electrochemical Process and Technology for Materials, Beijing University of Chemical Technology, Beijing 100029, China
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Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China
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1. Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China
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2. State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
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Received Date: 13 May 2014
Revised Date: 2 July 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 51003109, 51125007 and 51025314).

Poly(D,L-lactide-co-glycolide) (PLGA) microspheres were prepared by emulsion solvent evaporation method. The influences of inner aqueous phase, organic solvent, PLGA concentration on the morphology of microspheres were studied. The results showed that addition of porogen or surfactants to the inner aqueous phase, types of organic solvents and polymer concentration affected greatly the microsphere morphology. When dichloromethane was adopted as organic solvent, microspheres with porous structure were produced. When ethyl acetate served as organic solvent, two different morphologies were obtained. One was hollow microspheres with thin porous shell under a lower PLGA concentration, another was erythrocyte-like microspheres under a higher PLGA concentration. Three types of microspheres including porous, hollow core with thin porous shell (denoted by hollow in brief) and solid structures were finally selected for in vitro drug release tests. Bovine serum albumin (BSA) was chosen as model drug and encapsulated within the microspheres. The BSA encapsulation efficiency of porous, hollow and solid microspheres was respectively 90.4%, 79.8% and 0. And the ultimate accumulative release was respectively 74.5%, 58.9% and 0. The release rate of porous microspheres was much slower than that of hollow microspheres. The experiment results indicated that microspheres with different porous structures showed great potentials in controlling drug release behavior.
- PLGA,
- Porous microsphere,
- Morphology,
- BSA,
- Tissue engineering
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