Synthesis and Characterization of Chitosan-graft-Poly(lactic acid) Copolymer

Xu-feng Niu Feng Tian Li-zhen Wang Xiao-ming Li Gang Zhou Yu-bo Fan

Citation:  Xu-feng Niu, Feng Tian, Li-zhen Wang, Xiao-ming Li, Gang Zhou, Yu-bo Fan. Synthesis and Characterization of Chitosan-graft-Poly(lactic acid) Copolymer[J]. Chinese Journal of Polymer Science, 2014, 32(1): 43-50. doi: 10.1007/s10118-014-1369-1 shu

Synthesis and Characterization of Chitosan-graft-Poly(lactic acid) Copolymer

  • 基金项目:

    This work was financially supported by the National Natural Science Foundation of China (Nos. 11272038, 50803032, 11032012, 10925208, 11202017 and 11120101001), the Fundamental Research Funds for the Central Universities (No. YWF-13-T-RSC-024), the 111 Project (No. B13003), the International Joint Research Center of Aerospace Biotechnology and Medical Engineering, Ministry of Science and Technology of China, and the Program of Pearl River Young Talents of Science and Technology in Guangzhou, China (No. 2013Z2200010).

摘要: Chitosan-graft-poly(lactic acid) (CS-g-PLA) copolymer was synthesized through emulsion self-assembly in a water-in-oil (W/O) microemulsion. The water phase was composed of CS aqueous solution, while the oil phase was made up of PLA in chloroform. The W/O microemulsion was fabricated in the presence of surfactant span-80 and the self-assembly was performed between PLA and CS under the effect of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDCHCl). FTIR and 1H-NMR analysis indicated PLA was grafted onto the backbone of CS via the reaction between the carboxyl groups in PLA and the amino groups in CS. 1H-NMR characterization further revealed the grafting content of PLA was 16%. The obtained CS-g-PLA could self-assemble to form micelles, their size distributed in the range of 125-375 nm with average diameter of 142 nm. The present design integrates the favorable biological properties of CS and the excellent mechanical properties of PLA, which makes CS-g-PLA copolymer a promising candidate as a carrier for targeted bioactive molecules delivery.

English


    1. [1]

      Munch, E., Launey, M.E., Alsem, D.H., Saiz, E., Tomsia, A.P. and Ritchie, R.O., Science, 2008, 322(5907): 1516.[2]Mitragotri, S. and Lahann, J., Nat. Mater., 2009, 8(1): 15.[3]Williams, D.F., Biomaterials, 2009, 30(30): 5897.[4]Stuart, M.A.C., Huck, W.T.S., Genzer, J., Muller, M., Ober, C., Stamm, M., Sukhorukov, G.B., Szleifer, I., Tsukruk, V.V., Urban, M., Winnik, F., Zauscher, S., Luzinov, I. and Minko, S., Nat. Mater., 2010, 9(2): 101.[5]Huebsch, N. and Mooney, D[J].J., Nature.2009, 462(7272):426-[6]Place, E.S., Evans, N.D. and Stevens, M.M., Nat. Mater., 2009, 8(6): 457.[7]Bhattarai, N., Li, Z.S., Gunn, J., Leung, M., Cooper, A., Edmondson, D., Veiseh, O., Chen, M.H., Zhang, Y., Ellenbogen, R.G. and Zhang, M.Q., Adv. Mater., 2009, 21(27): 2792.[8]Feng, H. and Dong, C[J].M., Biomacromolecules.2006, 7(11):3069-[9]Li, G., Zhuang, Y.L., Mu, Q., Wang, M.Z. and Fang, Y.E., Carbohydr. Polym., 2008, 72(1): 60.[10]Wan, Y., Wu, H., Yu, A.X. and Wen, D.J., Biomacromolecules, 2006, 7(4): 1362.[11]Amidi, M. and Hennink, W.E., Adv. Drug. Deliver. Rev., 2010, 62(1): 1.[12]Boddohi, S. and Kipper, M[J].J., Adv. Mater.2010, 22(28):2998-[13]Sakurai, K., Maegawa, T. and Takahashi, T., Polymer, 2000, 41(19): 7051.[14]Fasl, H., Zemlji?, L.F., Goessler, W., Stana-Kleinschek, K. and Ribitsch, V., Macromol. Chem. Phys., 2012, 213(15): 1582.[15]Gupta, B., Revagade, N. and Hilborn, J., Prog. Polym. Sci., 2007, 32(4): 455.[16]Theryo, G., Jing, F., Pitet, L.M. and Hillmyer, M.A., Macromolecules, 2010, 43(18): 7394.[17]Niu, X.F., Luo, Y.F., Li, Y.G., Fu, C.H., Chen, J. and Wang, Y.L., J. Biomed. Mater. Res. Part A, 2008, 84A(4): 908.[18]Rasal, R.M., Janorkar, A[J].V. and Hirt, D.E., Prog. Polym. Sci.2010, 35(3):338-[19]Niu, X., Feng, Q., Wang, M., Guo, X. and Zheng, Q., Polym. Degrad. Stab., 2009, 94(2): 176.[20]Niu, X., Feng, Q., Wang, M., Guo, X. and Zheng, Q., J. Control. Release, 2009, 134(2): 111.[21]Fangkangwanwong, J., Akashi, M., Kida, T. and Chirachanchai, S., Macromol. Rapid Comm., 2006, 27(13): 1039.[22]Kuo, J.W., Swann, D[J].A. and Prestwich, G.D., Bioconjug. Chem.1991, 2(4):232-[23]Kurzer, F. and Douraghi-Zadeh, K., Chem. Rev., 1967, 67(2): 107.[24]Espartero, J.L., Rashkov, I., Li, S.M., Manolova, N. and Vert, M., Macromolecules, 1996, 29(10): 3535.

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  • 发布日期:  2014-01-05
  • 收稿日期:  2013-02-01
  • 修回日期:  2013-03-12
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