引用本文:
Yong Bin HAN, Jin Ping CHEN, Bai Ning LIU, Guo Qiang YANG, Yi LI. Stereochemistry Control in Direct 1α-Hydroxylation of 5, 6-trans-Vitamin D3 by Solid Support[J]. Chinese Chemical Letters,
2006, 17(2): 159-162.
Citation: Yong Bin HAN, Jin Ping CHEN, Bai Ning LIU, Guo Qiang YANG, Yi LI. Stereochemistry Control in Direct 1α-Hydroxylation of 5, 6-trans-Vitamin D3 by Solid Support[J]. Chinese Chemical Letters, 2006, 17(2): 159-162.
Citation: Yong Bin HAN, Jin Ping CHEN, Bai Ning LIU, Guo Qiang YANG, Yi LI. Stereochemistry Control in Direct 1α-Hydroxylation of 5, 6-trans-Vitamin D3 by Solid Support[J]. Chinese Chemical Letters, 2006, 17(2): 159-162.
Stereochemistry Control in Direct 1α-Hydroxylation of 5, 6-trans-Vitamin D3 by Solid Support
摘要:
A solid-phase synthesis of 1α-hydroxylation of 5, 6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity in oxidation step than classical protecting groups. The stereochemistry control is favored by using high crosslinkage polymer support in a poor solvent. This work may be of benefit to the synthesis of vitamin D system.
English
Stereochemistry Control in Direct 1α-Hydroxylation of 5, 6-trans-Vitamin D3 by Solid Support
Abstract:
A solid-phase synthesis of 1α-hydroxylation of 5, 6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity in oxidation step than classical protecting groups. The stereochemistry control is favored by using high crosslinkage polymer support in a poor solvent. This work may be of benefit to the synthesis of vitamin D system.
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Key words:
- Vitamin D3
- / solid-phase synthesis
- / stereochemistry control
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