引用本文:
Qiu Yun CHEN, Qing Shan LIU, Christopher J. SCHOFIELD. Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids[J]. Chinese Chemical Letters,
2006, 17(2): 156-158.
Citation: Qiu Yun CHEN, Qing Shan LIU, Christopher J. SCHOFIELD. Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids[J]. Chinese Chemical Letters, 2006, 17(2): 156-158.
Citation: Qiu Yun CHEN, Qing Shan LIU, Christopher J. SCHOFIELD. Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids[J]. Chinese Chemical Letters, 2006, 17(2): 156-158.
Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids
摘要:
Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factorinhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The results show that hydrophobic substitutes of 2-oxoglutaric acids have great influence on their inhibitor activity.
English
Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids
Abstract:
Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factorinhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The results show that hydrophobic substitutes of 2-oxoglutaric acids have great influence on their inhibitor activity.
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Key words:
- 2-Oxoglutatic acid analogues
- / inhibitor
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