First Total Synthesis of 6-Oxodendrolasinolide

Yi LI Tao ZHANG Yu Lin LI

引用本文: Yi LI,  Tao ZHANG,  Yu Lin LI. First Total Synthesis of 6-Oxodendrolasinolide[J]. Chinese Chemical Letters, 2006, 17(2): 147-149. shu
Citation:  Yi LI,  Tao ZHANG,  Yu Lin LI. First Total Synthesis of 6-Oxodendrolasinolide[J]. Chinese Chemical Letters, 2006, 17(2): 147-149. shu

First Total Synthesis of 6-Oxodendrolasinolide

  • 基金项目:

    This work was financially supported by the National Natural Science Foundation of China (Grant No. 20072012) and the Special Research Grant for Doctoral Sites in Chinese Universities (Grant No. 20010730001).

摘要: An efficient total synthesis of 6-oxodendrolasinolide 1, a new farnesane-based homosesquiterpene lactone, starting from geraniol 2 through twelve steps is described. Our work involved two key steps: (1) regioselective alkylation of the anion of vinyldithian 5 with allylic chloride 31, (2) Corey's oxidative lactionization method2.

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  • 收稿日期:  2005-05-30
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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