引用本文:
Xi Cun WANG, Jun Ke WANG, Zheng LI. Poly(ethylene glycol)-supported Liquid-phase Parallel Synthesis of Di (aryloxyacetyl) thiosemicarbazides[J]. Chinese Chemical Letters,
2004, 15(6): 635-638.
Citation: Xi Cun WANG, Jun Ke WANG, Zheng LI. Poly(ethylene glycol)-supported Liquid-phase Parallel Synthesis of Di (aryloxyacetyl) thiosemicarbazides[J]. Chinese Chemical Letters, 2004, 15(6): 635-638.
Citation: Xi Cun WANG, Jun Ke WANG, Zheng LI. Poly(ethylene glycol)-supported Liquid-phase Parallel Synthesis of Di (aryloxyacetyl) thiosemicarbazides[J]. Chinese Chemical Letters, 2004, 15(6): 635-638.
Poly(ethylene glycol)-supported Liquid-phase Parallel Synthesis of Di (aryloxyacetyl) thiosemicarbazides
摘要:
An efficient poly(ethylene glycol) (PEG)-supported liquid-phase parallel approach to di(aryloxyacetyl)thiosemicarbazides is described. PEG-bound phenol reacted with chloroacetic acid to afford PEG-bound phenyloxyacetic acid, which was readily converted into corresponding phenyloxyacetyl chloride. Subsequent nucleophilic substitution with ammonium thiocyanate followed by addition of aryloxyacetic acid hydrazides gave PEG-bound di(aryloxyacetyl)thiosemi-carbazides, which were easily cleaved to give the resulting library of 1-aryloxyacetyl-4-(4'-methoxylcarbonylphenyloxyacetyl)thiosemicarbazides in good to high yield and high purity.
English
Poly(ethylene glycol)-supported Liquid-phase Parallel Synthesis of Di (aryloxyacetyl) thiosemicarbazides
Abstract:
An efficient poly(ethylene glycol) (PEG)-supported liquid-phase parallel approach to di(aryloxyacetyl)thiosemicarbazides is described. PEG-bound phenol reacted with chloroacetic acid to afford PEG-bound phenyloxyacetic acid, which was readily converted into corresponding phenyloxyacetyl chloride. Subsequent nucleophilic substitution with ammonium thiocyanate followed by addition of aryloxyacetic acid hydrazides gave PEG-bound di(aryloxyacetyl)thiosemi-carbazides, which were easily cleaved to give the resulting library of 1-aryloxyacetyl-4-(4'-methoxylcarbonylphenyloxyacetyl)thiosemicarbazides in good to high yield and high purity.
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Key words:
- Liquid-phase synthesis
- / PEG
- / di(aryloxyacetyl)thiosemicarbazide
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