引用本文:
Ji Yun LIU, Shou Fang ZHANG. Synthesis of 1,2,3,4-Tetrahydro-1-Indolizinones and 3-Methyl-1,2-dihydro-1-Pyrrolizinones[J]. Chinese Chemical Letters,
1997, 8(7): 577-578.
Citation: Ji Yun LIU, Shou Fang ZHANG. Synthesis of 1,2,3,4-Tetrahydro-1-Indolizinones and 3-Methyl-1,2-dihydro-1-Pyrrolizinones[J]. Chinese Chemical Letters, 1997, 8(7): 577-578.
Citation: Ji Yun LIU, Shou Fang ZHANG. Synthesis of 1,2,3,4-Tetrahydro-1-Indolizinones and 3-Methyl-1,2-dihydro-1-Pyrrolizinones[J]. Chinese Chemical Letters, 1997, 8(7): 577-578.
Synthesis of 1,2,3,4-Tetrahydro-1-Indolizinones and 3-Methyl-1,2-dihydro-1-Pyrrolizinones
摘要:
4-(1-Pyrrolyl) butanenitrile (4),the key intermediate for the synthesis of 1,2,3,4-tetrahydro-1-indolizinone,was prepared with Clauson-Kass reation.When pyrrole reacted with 4-bromobutanenitrile in PEG-400 dimethyl ether catalyzed by NaOH,3-(1-pyrrolyl) butanenitrile was obtained.The nitrites were converted into the corresponding ketones by Hoesch reaction.Some of the ketone derivatives were prepared.
English
Synthesis of 1,2,3,4-Tetrahydro-1-Indolizinones and 3-Methyl-1,2-dihydro-1-Pyrrolizinones
Abstract:
4-(1-Pyrrolyl) butanenitrile (4),the key intermediate for the synthesis of 1,2,3,4-tetrahydro-1-indolizinone,was prepared with Clauson-Kass reation.When pyrrole reacted with 4-bromobutanenitrile in PEG-400 dimethyl ether catalyzed by NaOH,3-(1-pyrrolyl) butanenitrile was obtained.The nitrites were converted into the corresponding ketones by Hoesch reaction.Some of the ketone derivatives were prepared.
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