Citation:
WANG Yongmeib, ZHANG Zhengpua, WANG Zhenb, MENG Jibenb, Hodge P.c. THE ASYMMETRIC SYNTHESIS OF AMINO ACIDS UNDER POLYMER-SUPPORTED PHASE TRANSFER CATALYTIC CONDITION*[J]. Chinese Journal of Polymer Science,
1998, 16(4): 356-361.
THE ASYMMETRIC SYNTHESIS OF AMINO ACIDS UNDER POLYMER-SUPPORTED PHASE TRANSFER CATALYTIC CONDITION*
摘要:
The optical α-amino acids were synthesized under room temperature byalkylation of N-(diphenyl methylene) glycine t-butyl ester under polymer-supported phasetransfer conditions using polymer-supported cinchonine (or quinine) alkaloids as chiralphase transfer catalysts and dichloromethane as solvent, followed by hydrolysis of theabove intermediates introduced to the final products-optical α-amino acids. This is anew method for the asymmetric synthesis of α-amino acids. The influences of catalyst,temperature,substrates,and organic solvents on the chemical yield and optical purities of products were stydied.
English
THE ASYMMETRIC SYNTHESIS OF AMINO ACIDS UNDER POLYMER-SUPPORTED PHASE TRANSFER CATALYTIC CONDITION*
Abstract:
The optical α-amino acids were synthesized under room temperature byalkylation of N-(diphenyl methylene) glycine t-butyl ester under polymer-supported phasetransfer conditions using polymer-supported cinchonine (or quinine) alkaloids as chiralphase transfer catalysts and dichloromethane as solvent, followed by hydrolysis of theabove intermediates introduced to the final products-optical α-amino acids. This is anew method for the asymmetric synthesis of α-amino acids. The influences of catalyst,temperature,substrates,and organic solvents on the chemical yield and optical purities of products were stydied.
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