Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid

Citation: Yu-jie Cao, Dan Zhu, To Ngai, Ling Qin, Chi Wu, Jian Shen. Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid[J]. Chinese Journal of Polymer Science, 2014, 32(4): 497-508. doi: 10.1007/s10118-014-1421-1 shu

Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid

Yu-jie Cao ^1, ,
Dan Zhu ^{1,
,} ,
To Ngai ^2, ,
Ling Qin ^3, ,
Chi Wu ^2, ,
Jian Shen ^1,

1.
Jiangsu Key Laboratory of Bio-functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China
2.
Department of Chemistry, The Chinese University of Hong Kong, Shatin N.T., Hong Kong, China
3.
The Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin N.T., Hong Kong, China

通讯作者: Dan Zhu,

基金项目:
This work was financially supported by the National Natural Scientific Foundation of China (Nos. 50773077, 20934005 and 51273091) and the Hong Kong Special Administration Region Earmarked Projects (CUHK4042/09P, 2160396).

摘要: Composite biomaterials made of biodegradable polylactic acid (PLA) and bioactive magnesium (Mg) salt are developed for orthopaedic implants or metal implant coatings. The releasing of Mg salt into the biological environment benefits the bone growth, while with the releasing of Mg salt and degradation of PLA there forms a porous scaffold for tissue engineering. The size and morphology of the salt and voids are adjustable with such preparation conditions as salt content, pH of casting solution, and the solidification rate, so that we can control the salt releasing and degradation rate of PLA. Dielectric spectroscopy is used to investigate the dispersive structures of Mg salt and voids in the polymer matrix and to monitor the in situ releasing of Mg salts in the simulated body fluid (SBF). The current study provides us with an orthopedic biomaterial with controllable multi-phase structures, and a tool to investigate the in vivo behaviors of biomaterials.

关键词:

English

Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid

Yu-jie Cao ^1, ,
Dan Zhu ^{1,
,} ,
To Ngai ^2, ,
Ling Qin ^3, ,
Chi Wu ^2, ,
Jian Shen ^1,

1.
Jiangsu Key Laboratory of Bio-functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China
2.
Department of Chemistry, The Chinese University of Hong Kong, Shatin N.T., Hong Kong, China
3.
The Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin N.T., Hong Kong, China

Corresponding author: Dan Zhu,

Received Date: 12 August 2013
Revised Date: 13 December 2013
Available Online: 05 April 2014
Fund Project:
This work was financially supported by the National Natural Scientific Foundation of China (Nos. 50773077, 20934005 and 51273091) and the Hong Kong Special Administration Region Earmarked Projects (CUHK4042/09P, 2160396).

Abstract: Composite biomaterials made of biodegradable polylactic acid (PLA) and bioactive magnesium (Mg) salt are developed for orthopaedic implants or metal implant coatings. The releasing of Mg salt into the biological environment benefits the bone growth, while with the releasing of Mg salt and degradation of PLA there forms a porous scaffold for tissue engineering. The size and morphology of the salt and voids are adjustable with such preparation conditions as salt content, pH of casting solution, and the solidification rate, so that we can control the salt releasing and degradation rate of PLA. Dielectric spectroscopy is used to investigate the dispersive structures of Mg salt and voids in the polymer matrix and to monitor the in situ releasing of Mg salts in the simulated body fluid (SBF). The current study provides us with an orthopedic biomaterial with controllable multi-phase structures, and a tool to investigate the in vivo behaviors of biomaterials.

Key words:

1. [1]
  Lasprolla, A.J.R., Martinez, G.A.R., Lunelli, B.H., Jardini, A.L. and Filho, R.M., Biotech. Adv., 2012, 30: 321
2. [2]
  Chen, Y., Song, Y., Zhang, S., Li, J., Zhao, C. and Zhang, X., Biomed. Mater., 2011, 6: 025005
3. [3]
  Rezwan, K., Chen, Q.Z., Blaker, J.J. and Boccaccini, A.R., Biomaterials, 2006, 27: 3413
4. [4]
  Wang, G. and Zreiqat, H., Materials, 2010, 3: 3994
5. [5]
  Mourin, V., Cattalini, J.P. and Boccaccini, A.R., J. R. Soc. Interface, 2012, 9: 401
6. [6]
  Zhou, H., Lawrence, J.G. and Bhaduri, S.B., Acta Biomaterialia, 2012, 8: 1999
7. [7]
  Wang, J., Tang, J., Zhan, P., Li, Y., Wang, J., Lai, Y. and Qin, L., J. Biomed. Mater. Res. B Appl. Biomater, 2012, 100B(6): 1691
8. [8]
  Gu, X., Xie, X., Li, N., Zheng, Y. and Qin, L., Acta Biomaterialia, 2012, 8: 2360
9. [9]
  Niki, Y., Matsumoto, H., Suda, Y., Otani, T., Fujikawa, K., Toyama, Y., Hisamori, N. and Nozue, A., Biomaterials, 2003, 24: 1447
10. [10]
  Vormann, J., Mol. Aspects Med., 2003, 24: 27
11. [11]
  Balazs, A.C., Emrick, T. and Russell, T.P., Science, 2006, 314: 1107
12. [12]
  Jancar, J., Douglas, J.F., Starr, F.W., Kumar, S.K., Cassagnau, P., Lesser, A.J., Sternstein, S.S. and Buehler, M.J., Polymer, 2010, 51: 3321
13. [13]
  Steeman, P.A.M. and van Turnhout, J., in Broadband Dielectric Spectroscopy, ed. By Kremer, F. and Schonhals, A., Springer, New York, 2003, p. 495
14. [14]
  Brosseau, C., J. Phys. D: Appl. Phys., 2006, 39: 1277
15. [15]
  Williams, G. and Thomas, D.K., Novocontrol Application Note Dielectrics, 1998, 3: 1
16. [16]
  Achour, M.E., Brosseau, C. and Carmona, F., J. Appl. Phys., 2008, 103: 094103
17. [17]
  Lu, H., Zhang, X. and Zhang, H., J. Appl. Phys., 2006, 100: 054104
18. [18]
  Zhu, D., Bin, Y. and Matsuo, M., J. Polym. Sci. Part B: Polym. Phys., 2007, 45: 1037
19. [19]
  Zhu, D., Zhang, J., Bin, Y., Xu, C., Shen, J. and Matsuo, M., J. Phys. Chem. A, 2012, 116: 2024
20. [20]
  Tanaka, T. and Lloyd, D.R., J. Membr. Sci., 2004, 238: 65
21. [21]
  Popielarz, R., Chiang, C.K., Nozaki, R. and Obrzut, J., Macromolecules, 2001, 34: 5910
22. [22]
  Haas, C.K. and Torkelson, J.M., Phys. Rev. E, 1997, 55: 3191
23. [23]
  Tanaka, H., Phys. Rev. Lett., 1994, 72: 1702
24. [24]
  McMaster, L.P., in Copolymers, Polyblends, and Composites, Vol. 142, ed. by Platzer, N.A.J., ACS, New York, 1975, p. 43
25. [25]
  Dyre, J.C., J. Appl. Phys., 1988, 64: 2456
26. [26]
  Kremer, F., Dielectric Newsletter, 2002, Issue April: 4
27. [27]
  Wubbenhorst, M. and van Turnhout, J., Dielectric Newsletter, 2000, Issue November: 1
28. [28]
  Namikawa, H., J. Non-Cryst. Sol., 1975, 18: 173
29. [29]
  Jonscher, A.K., Nature, 1977, 267: 673
30. [30]
  Hanai, T., The heterogeneous structure and the permittivity (in Japanese), Yoshioka, Tokyo, 1999, p. 61

扫一扫看文章

计量

PDF下载量: 0
文章访问数: 2076
HTML全文浏览量: 227

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid

通讯作者: Dan Zhu,

English

Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid

Corresponding author: Dan Zhu,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid

通讯作者: Dan Zhu,

English

Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid

Corresponding author: Dan Zhu,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs