English

• As a widely applied strategy to significantly modulate the lipophilic properties, electronic, metabolic stability and bioavailability of functional molecules [1–6], the introduction of fluorine atom into organic compounds has been found widespread applications in almost all aspects of the chemical industry, ranging from pharmaceuticals, agrochemicals and materials [7–13]. However, due to the limited variety of monofluorinating agents [14–33], compared with the construction of trifluoromethyl compounds [34–46] and difluoroalkyl compounds [47–58], monofluoroalkylation especially the production of α-fluoroketones have been less intensively investigated.

  α-Fluoroketones as valuable building blocks are easily found in the pharmaceutical and bioactive molecules (Scheme 1a) [59,60]. Accordingly, several methods for the synthesis of α-fluoro-arylketones have been developed via direct electrophilic/nucleophilic fluorination methods (Scheme 1b) [61–63]. The synthesis of α-fluoro-arylketones using α-fluorocarbonyl compounds as building block through the transition metals catalyzed cross-coupling was another alter alternative choice. Recently, Qing [64,65], Shreeve [66], and Wu [67] have accomplished the synthesis of α-fluoro-arylketones via palladium-catalyzed α-fluorocarbonyl compounds coupling reactions with phenylboronic acids or bromobenzenes. Moreover, Negishi and Suzuki cross-coupling of α-halo-α-fluoroketones have been shown to be effective strategies to obtain α-fluoro-arylketones [68,69]. However, to the best of our knowledge, only a few cases of directly constructing α-alkyl-α-fluoro-alkylketones have been reported. Belén has accomplished iridium-catalysed tandem isomerisation/C–F bond formation from allylic alcohols and selectfluors to prepare α-fluorinated ketones as single constitutional isomers [70]. Then Pher. G. Andersson has disclosed a straightforward method for the preparation of chiral α-alkyl-α-fluoro-alkylketones (Scheme 1c) [71]. However due to the site selectivity and substrate restriction, it still remains huge challenge to synthesize α-alkyl-α-fluoro-alkylketones easily and efficiently.

  Scheme 1

  

  Scheme 1.  Synthesis of α-fluoroketones: Status quo & challenges.

  DownLoad: Full-Size Img PowerPoint

  Monofluoroalkyl triflates developed by our group could be used as a leveraging modular synthetic scaffold in divergent syntheses of aliphatic monofluorides [72]. Meanwhile we have simplified the previous synthetic route in a one-step procedure by sequential addition of trifluoromethylsulfonic anhydride and Et₃N·HF to the mixture of aldehydes and lutidine in dichloromethane. As expected, a series of alkyl aldehydes were smoothly transformed to the desired monofluoroalkyl triflates in a rapid and efficient fashion with high yields. To address the issues and challenges in synthesizing α-alkyl-α-fluoro-alkylketones, we envisaged monofluoroalkyl triflates as the monofluoroalkylating reagent for synthesis the desired products via nickel-catalyzed reductive coupling reactions with cheap and readily available alkyl carboxylic acids.

  Herein, we describe a novel and efficient nickel-catalyzed reductive coupling reaction of monofluoroalkyl triflates with alkyl carboxylic acids, giving a series of α-alkyl-α-fluoro-alkylketones in moderate to high yields (Scheme 1d). The transformation demonstrated broad functional group compatibility and mild conditions. This method could provide a highly efficient and selective synthetic route to α-fluoroketones-containing pharmaceutical design and development.

  Our initial studies commenced with 3-phenylpropionic acid (1a) as the pilot substrate, 1-fluoro-3-phenylpropyl trifluoromethanesulfonate (2a) as the mono-fluoroalkylating reagent and Boc₂O (2.0 equiv.) was chosen as the activating agent to generate mixed anhydride in situ from carboxylic acids (Table 1). First, using Ni(acac)₂ (10 mol%), bipyridine L₁ (15 mol%), Zn (3.0 equiv.) as the reductant, MgCl₂ (1.5 equiv.) as the additive and THF (0.2 mol/L) as the solvent, the desired product 3 was obtained in 14% yield (entry 1). Unfortunately, the yield of 3 could not been improved when polar solvents such as DMF, CH₃CN and NMP were used (< 10%, entries 2–4). Then a series of mixed solvents were tested (for details, see Supporting information). To our delight, THF and CH₃CN component solvent could afford the desired product with 38% yield (entries 5–7). To further improved the yield, various nickel catalysts were investigated, which indicated that Ni(NO₃)₂·6H₂O was the best choice to catalyze the reaction (entries 7–11). Considered the importance of the ligand for this transformation, ligands screening was then tested. The results showed that the conversion efficiency was promoted when the electron-donating substituents were introduced on the C4-position of bipyridine, the corresponding product 3 with 62% yield could be provided by using L₂ (entry 12). When L₃ replacing the Me- on the ligand with more electron-donating group MeO- was investigated, the yield of 3 was enhanced to 67% (entry 13). L₄ with an electron-withdrawing substituent (4-CF₃) would lead to a significantly lower yield (entry 14). And higher yield could not be obtained by using phenanthroline ligands (entries 15 and 16). We then reduced TBAI to 1.2 equiv., which could further increase the yield to 75% (entry 17). It was a critical factor that TBAI and 1-fluoro-3-phenylpropyl trifluoromethanesulfonate (2a) were added after the stirring of the other reactants for 30 min. Finally, the α-alkyl-α-fluoro-alkylketone 3 could be obtained with a separation yield of 80% by step feeding (entries 18 and 19).

  Table 1

  

  Table 1.  Optimization of reaction conditions of nickel-catalyzed reductive coupling reaction of monofluoroalkyl triflates with alkyl carboxylic acids. ^a

  DownLoad: CSV

  With the optimized conditions established for this nickel-catalyzed reductive mono-fluoroalkylation in hand, we next started to test the substrate tolerance of this transformation (Scheme 2) First, a series of alkyl carboxylic acids were well compatible with this catalytic system for cross-coupling with 1-fluoro-3-phenylpropyl trifluoromethanesulfonate (2a). Those carboxylicacids bearing different steric properties or long chains alkyl furnished the corresponding α-alkyl-α-fluoro-alkylketone with 50%−84% yields (4–7). It should be mentioned that a series of functional groups including alkene (8, 9), chloro (10) and ester (11) were well tolerated in this catalytic method. Remarkably, the alkyl halide, alkyl ester, and olefin can serve as versatile synthetic handles for further structural elaborations. This monofluoroalkylation proceeded well with 1-naphthyl (12) and 1-pyrenyl (13) substituted alkyl carboxylic acids and gave 64%−78% yields. The substituent effect on the phenyl rings was next examined, and good yields were observed with both electron-withdrawing and electron-donating groups, such as fluoro (14), chloro (15), bromo (16), methoxy (17), 3,4-methylenedioxy (18), ester (19) and nitrile (20) were all well tolerated, which furnished the corresponding products in 43%−73% yields. To our delight, different heterocycles such as furan (21) and thiofuran (22) were also compatible and gave 78%−82% yields.

  Scheme 2

  

  Scheme 2.  Scope of nickel-catalyzed reductive coupling reaction of monofluoroalkyl triflates with alkyl carboxylic acids. Reaction conditions were as follows: 1 (0.2 mmol), 2 (0.3 mmol), [Ni] (10 mol%), L₃ (15 mol%), TBAI (1.2 equiv.), Boc₂O (0.4 mmol, 2.0 equiv.), MgCl₂ (0.3 mmol, 1.5 equiv.), Zn (0.6 mmol, 3.0 equiv.), THF: CH₃CN (0.6 mL: 0.4 mL), 35 ℃, 12 h.

  DownLoad: Full-Size Img PowerPoint

  Next, we moved on to the scope of monofluoroalkylating reagents (Scheme 2). It should be noted that monofluoroalkyl triflates containing simple alkyl chains or cyclohexyl could also be successfully transformed into corresponding products with 71%−80% yields (23, 24, 38, 39). Notably, monofluoroalkyl triflates installed with a terminal chloro group on the alkyl chains were also applied onto different alkyl carboxylic acids and moderate yields of α-alkyl-α-fluoro-alkylketones were accessed (25, 36, 37). To our delight, both electron-donating groups such as methoxy (28, 29) and electron-withdrawing groups such as fluoro (26), chloro (27), ester (30) on the aryl rings were well compatible with this transformation, affording α-alkyl-α-fluoro-alkylketones with 60%−82% yields. Meanwhile, it was also suitable for the 1-naphthalene derived monofluoroalkyl triflates, which gave the desired products 31–35 in 56%−76% yields. And different alkyl carboxylic acids and monofluoroalkyl triflates can be coupled well under this strategy to obtain corresponding products (39–41).

  Base on the previous reports [73–75], a propose a plausible mechanism have been depicted in Scheme 3. In the presence of Zn powder, Ni(NO₃)₂·6H₂O can be reduced to Ni(0) species A to start the catalytic process. Acid anhydride in situ formation from Boc₂O and alkyl carboxylic acids followed by oxidative addition to A, giving Ni(Ⅱ) species B. Then radical oxidation to afford R¹CO-L_nNi(Ⅲ)-R_f (intermediate C) and subsequent afford desired α-alkyl-α-fluoro-alkylketones and R¹(CO)O-L_nNi(Ⅰ) species D via reductive elimination. The alkyl radical and R¹(CO)O-L_nNi(Ⅱ)-X can be generated by Ni(Ⅰ) species D which undergo a SET process with R_f-I. Finally, intermediate E can be reduced to Ni(0) species A by zinc powder in the presence of MgCl₂ to complete the cycle.

  Scheme 3

  

  Scheme 3.  Suggested catalytic cycle.

  DownLoad: Full-Size Img PowerPoint

  In summary, we have developed a practical and creationary strategy for the fast synthesis of α-alkyl-α-fluoro-alkylketones. With alkyl carboxylic acids a low-cost industrial raw material, served as the acyl source, a general and efficient nickel-catalyzed reductive cross-coupling with monofluoroalkyl triflates has been established. this method demonstrated mild conditions and the excellent functional-group tolerance. α-Fluoroketones-containing pharmaceutical design and development could be completed though this efficient strategy.

  Declaration of competing interest

  The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

  Acknowledgments

  We gratefully acknowledge the financial support of the National Key R&D Program of China (No. 2021YFF0701700), the National Science Foundation of China (Nos. 22271264, 21971228).

  Supplementary materials

  Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.cclet.2023.108490.

  
  
• 1. [1]

     J. Wang, M. Sánchez-Roselló. J.L. Aceña, et al., Chem. Rev. 114 (2014) 2432–2506. doi: 10.1021/cr4002879

  2. [2]

     D. O'Hagan, Chem. Soc. Rev. 37 (2008) 308–319. doi: 10.1039/B711844A

  3. [3]

     K. Mgller, C. Faeh, F. Diederich, Science 317 (2007) 1881–1886. doi: 10.1126/science.1131943

  4. [4]

     S. Purser, P.R. Moore, S. Swallow, V. Gouverneur, Chem. Soc. Rev. 37 (2008) 320–330. doi: 10.1039/B610213C

  5. [5]

     W.K. Hagmann, J. Med. Chem. 51 (2008) 4359–4369. doi: 10.1021/jm800219f

  6. [6]

     C. Ni, J. Hu, Chem. Soc. Rev. 45 (2016) 5441–5454. doi: 10.1039/C6CS00351F

  7. [7]

     P. Kirsch, Modern Fluoroorganic Chemistry: Synthesis Reactivity, Applications, 2nd Ed., Wiley-VCH, Weinheim, 2013.

  8. [8]

     M.B. van Niel, I. Collins, M.S. Beer, et al., J. Med. Chem. 42 (1999) 2087–2104. doi: 10.1021/jm981133m

  9. [9]

     R. Berger, G. Resnati, P. Metrangolo, E. Weber, J. Hulliger, Chem. Soc. Rev. 40 (2011) 3496–3508. doi: 10.1039/c0cs00221f

  10. [10]

      Y. Zhou, J. Wang, Z. Gu, et al., Chem. Rev. 116 (2016) 422–518. doi: 10.1021/acs.chemrev.5b00392

  11. [11]

      N.A. Meanwell, J. Med. Chem. 61 (2018) 5822–5880. doi: 10.1021/acs.jmedchem.7b01788

  12. [12]

      F. Ibba, T.D.W. Claridge, V. Gouverneur, et al., J. Am. Chem. Soc. 142 (2020) 19731–19744. doi: 10.1021/jacs.0c09832

  13. [13]

      J. He, Z. Li, G. Dhawan, et al., Chin. Chem. Lett. 34 (2023) 107578. doi: 10.1016/j.cclet.2022.06.001

  14. [14]

      Y. Zhao, B. Gao, C. Ni, J. Hu, Org. Lett. 14 (2012) 6080–6083. doi: 10.1021/ol3029737

  15. [15]

      C. Guo, X. Yue, F.L. Qing, Synthesis 11 (2010) 1837–1844.

  16. [16]

      X. Zhang, W.M. Qiu, D.J. Burton, Tetrahedron Lett. 40 (1999) 2681–2684. doi: 10.1016/S0040-4039(99)00305-6

  17. [17]

      W.K. Tang, Z.W. Xu, J. Xu, et al., Org. Lett. 21 (2019) 196–200. doi: 10.1021/acs.orglett.8b03656

  18. [18]

      Y. Zhao, C. Ni, F. Jiang, et al., ACS Catal. 3 (2013) 631–634. doi: 10.1021/cs4000574

  19. [19]

      X. Jiang, S. Sakthivel, K. Kulbitski, G. Nisnevich, M. Gandelman, J. Am. Chem. Soc. 136 (2014) 9548–9551. doi: 10.1021/ja504089y

  20. [20]

      J. Hu, B. Gao, L. Li, C. Ni, J. Hu, Org. Lett. 17 (2015) 3086–3089. doi: 10.1021/acs.orglett.5b01361

  21. [21]

      Y.M. Su, G.S. Feng, Z.Y. Wang, Q. Lan, X.S. Wang, Angew. Chem. Int. Ed. 54 (2015) 6003–6007. doi: 10.1002/anie.201412026

  22. [22]

      L. An, Y.L. Xiao, Q.Q. Min, X. Zhang, Angew. Chem. Int. Ed. 54 (2015) 9079–9083. doi: 10.1002/anie.201502882

  23. [23]

      Y. Wu, H.R. Zhang, Y.X. Cao, Q. Lan, X.S. Wang, Org. Lett. 18 (2016) 5564–5567. doi: 10.1021/acs.orglett.6b02803

  24. [24]

      J. Sheng, H.Q. Ni, G. Liu, Y. Li, X.S. Wang, Org. Lett. 19 (2017) 4480–4483. doi: 10.1021/acs.orglett.7b02012

  25. [25]

      N.Y. Wu, X.H. Xu, F.L. Qing, ACS Catal. 9 (2019) 5726–5731. doi: 10.1021/acscatal.9b01530

  26. [26]

      H. Yin, J. Sheng, K.F. Zhang, et al., Chem. Commun. 55 (2019) 7635–7638. doi: 10.1039/c9cc03737c

  27. [27]

      N.A. Beare, J.F. Hartwig, J. Org. Chem. 67 (2002) 541–555. doi: 10.1021/jo016226h

  28. [28]

      E. Cosimi, J. Saadi, H. Wennemers, Org. Lett. 18 (2016) 6014–6017. doi: 10.1021/acs.orglett.6b02795

  29. [29]

      J. Sheng, H.Q. Ni, S.X. Ni, et al., Angew. Chem. Int. Ed. 60 (2021) 15020–15027. doi: 10.1002/anie.202102481

  30. [30]

      S.X. Ni, Y.L. Li, H.Q. Ni, et al., Chin. Chem. Lett. 34 (2023) 107614. doi: 10.1016/j.cclet.2022.06.037

  31. [31]

      F.L. Qing, X.Y. Liu, J.A. Ma, et al., CCS Chem. 4 (2022) 2518–2549. doi: 10.31635/ccschem.022.202201935

  32. [32]

      Y. Li, W. Liu, Z.Y. Liu, et al., CCS Chem. 4 (2022) 2888–2896. doi: 10.31635/ccschem.021.202101395

  33. [33]

      Y. Hu, J. Luo, C. Lü, Chin. Chem. Lett. 21 (2010) 151–154. doi: 10.1016/j.cclet.2009.10.014

  34. [34]

      Y.Z. Cheng, J. Ma, Y. Zhang, S.Y. Yu, Adv. Synth. Catal. 356 (2014) 2859–2866. doi: 10.1002/adsc.201400504

  35. [35]

      L. Li, Q.Y. Chen, Y. Guo, J. Fluorine Chem. 167 (2014) 79–83.

  36. [36]

      Y.Y. Yu, G.I. Georg, Adv. Synth. Catal. 356 (2014) 3510–3518. doi: 10.1002/adsc.201400417

  37. [37]

      B. Sahoo, J.L. Li, F. Glorius, Angew. Chem. Int. Ed. 54 (2015) 11577–11580. doi: 10.1002/anie.201503210

  38. [38]

      R. Tomita, T. Koike, M. Akita, Angew. Chem. Int. Ed. 54 (2015) 12923–12927. doi: 10.1002/anie.201505550

  39. [39]

      N. Noto, T. Koike, M. Akita, J. Org. Chem. 81 (2016) 7064–7071. doi: 10.1021/acs.joc.6b00953

  40. [40]

      J.S. Lin, B. Tan, X.Y. Liu, J. Am. Chem. Soc. 138 (2016) 9357–9360. doi: 10.1021/jacs.6b04077

  41. [41]

      H. Xiao, Z. Liu, H. Shen, et al., Chem 5 (2019) 940–949. doi: 10.1016/j.chempr.2019.02.006

  42. [42]

      H. Wang, Y. Xie, Y. Zhou, N. Cen, W. Chen, Chin. Chem. Lett. 33 (2022) 221–224. doi: 10.1016/j.cclet.2021.06.008

  43. [43]

      B.B. Wu, J. Xu, K.J. Bian, Q. Gao, X.S. Wang, J. Am. Chem. Soc. 144 (2022) 6543–6550. doi: 10.1021/jacs.2c01422

  44. [44]

      H. Luo, Y. Zhao, D. Wang, M. Wang, Z. Shi, Green Synth. Catal. 1 (2020) 134–142. doi: 10.1016/j.gresc.2020.08.002

  45. [45]

      Y. Dai, F. Wang, S. Zhu, L. Chu, Chin. Chem. Lett. 33 (2022) 4074–4078. doi: 10.1016/j.cclet.2021.12.050

  46. [46]

      N. Meng, Y. Lv, X. Zhao, W. Wei, Chin. Chem. Lett. 32 (2021) 258–262. doi: 10.1016/j.cclet.2020.11.034

  47. [47]

      Z. Feng, Q.Q. Min, Y.L. Xiao, B. Zhang, X. Zhang, Angew. Chem. Int. Ed. 53 (2014) 1669–1673. doi: 10.1002/anie.201309535

  48. [48]

      M.K. Schwaebe, J.R. McCarthy, J.P. Whitten, Tetrahedron Lett. 41 (2000) 791–794. doi: 10.1016/S0040-4039(99)02212-1

  49. [49]

      Y.J. Chen, L.K. Li, Y.Y. Ma, Z.P. Li, J. Org. Chem. 84 (2019) 5328–5338. doi: 10.1021/acs.joc.9b00339

  50. [50]

      X. Huang, Y. Zhang, C. Zhang, et al., Angew. Chem. Int. Ed. 58 (2019) 5956–5961. doi: 10.1002/anie.201900745

  51. [51]

      H.Y. Zhao, X. Gao, S. Zhang, X. Zhang, Org. Lett. 21 (2019) 1031–1036. doi: 10.1021/acs.orglett.8b04070

  52. [52]

      H. Chen, J. Wang, J. Wu, Y. Kuang, F. Wu, J. Fluorine Chem. 200 (2017) 41–46. doi: 10.1016/j.jfluchem.2017.06.003

  53. [53]

      J.X. Wang, J.J. Wu, H. Chen, S.W. Zhang, F.H. Wu, Chin. Chem. Lett. 26 (2015) 1381–1384. doi: 10.1016/j.cclet.2015.07.007

  54. [54]

      D. Wang, J. Wu, J. Huang, et al., Tetrahedron 73 (2017) 3478–3484. doi: 10.1016/j.tet.2017.05.021

  55. [55]

      J. Liang, G. Huang, P. Peng, et al., Adv. Synth. Catal. 360 (2018) 2221–2227. doi: 10.1002/adsc.201701569

  56. [56]

      X. Chen, Z. Zhu, S. Liu, Y.H. Chen, X. Shen, Chin. Chem. Lett. 33 (2022) 2391–2396. doi: 10.1016/j.cclet.2021.10.083

  57. [57]

      W. Wu, Y. You, Z. Weng, Chin. Chem. Lett. 33 (2022) 4517–4530. doi: 10.1016/j.cclet.2022.01.038

  58. [58]

      J. Li, W. Xi, S. Liu, et al., Chin. Chem. Lett. 33 (2022) 3007–3011. doi: 10.1016/j.cclet.2021.12.002

  59. [59]

      S.D. Putnam, M. Castanheira, G.J. Moet, D.J. Farrell, R.N. Jones, Diagn. Microbiol. Infect. Dis. 66 (2010) 393–401. doi: 10.1016/j.diagmicrobio.2009.10.013

  60. [60]

      P.A. Champagne, J.F. Paquin, Chem. Rev. 115 (2015) 9073–9174. doi: 10.1021/cr500706a

  61. [61]

      T. Ishimaru, N. Shibata, T. Horikawa, et al., Angew. Chem. Int. Ed. 47 (2008) 4157–4161. doi: 10.1002/anie.200800717

  62. [62]

      H. Teare, E.G. Robins, E. Arstad, S.K. Luthra, V. Gouverneur, Chem. Commun. ˚ (2007) 2330–2332.

  63. [63]

      W. Zhang, J. Hu, Adv. Synth. Catal. 352 (2010) 2799–2804. doi: 10.1002/adsc.201000499

  64. [64]

      C. Guo, R.W. Wang, Y. Guo, F.L. Qing, J. Fluorine Chem. 133 (2012) 86–96. doi: 10.1016/j.jfluchem.2011.08.004

  65. [65]

      C. Guo, R.W. Wang, F.L. Qing, J. Fluorine Chem. 143 (2012) 135–142. doi: 10.1016/j.jfluchem.2012.05.001

  66. [66]

      Y. Guo, B. Twamley, J.M. Shreeve, Org. Biomol. Chem. 7 (2009) 1716–1722. doi: 10.1039/b900311h

  67. [67]

      J. Zhou, X. Fang, T.L. Shao, X.Y. Yang, F.H. Wu, J. Fluorine Chem. 191 (2016) 54–62. doi: 10.1016/j.jfluchem.2016.09.016

  68. [68]

      Y.F. Liang, G.C. Fu, J. Am. Chem. Soc. 136 (2014) 5520–5524. doi: 10.1021/ja501815p

  69. [69]

      J. Liang, J. Han, J. Wu, et al., Org. Lett. 21 (2019) 6844–6849. doi: 10.1021/acs.orglett.9b02474

  70. [70]

      N. Ahlsten, B. Martín-Matute, Chem. Commun. 47 (2011) 8331–8333. doi: 10.1039/c1cc12653a

  71. [71]

      S. Ponra, J. Yang, S. Kerdphon, P.G. Andersson, Angew. Chem. Int. Ed. 58 (2019) 9282–9287. doi: 10.1002/anie.201903954

  72. [72]

      B.B. Wu, J. Xu, Q. Gao, et al., Angew. Chem. Int. Ed. 61 (2022) e202208938. doi: 10.1002/anie.202208938

  73. [73]

      C. Zhao, X. Jia, X. Wang, H. Gong, J. Am. Chem. Soc. 136 (2014) 17645–17651. doi: 10.1021/ja510653n

  74. [74]

      J.B. Diccianni, T. Diao, Trends Chem. 1 (2019) 830–844. doi: 10.1016/j.trechm.2019.08.004

  75. [75]

      C.S. Day, Á. Rentería-Gómez, S.J. Ton, et al., Nat. Catal. 6 (2023) 244–253. doi: 10.1038/s41929-023-00925-4

• 

  Scheme 1  Synthesis of α-fluoroketones: Status quo & challenges.

  下载: 全尺寸图片 幻灯片
  

  Scheme 2  Scope of nickel-catalyzed reductive coupling reaction of monofluoroalkyl triflates with alkyl carboxylic acids. Reaction conditions were as follows: 1 (0.2 mmol), 2 (0.3 mmol), [Ni] (10 mol%), L₃ (15 mol%), TBAI (1.2 equiv.), Boc₂O (0.4 mmol, 2.0 equiv.), MgCl₂ (0.3 mmol, 1.5 equiv.), Zn (0.6 mmol, 3.0 equiv.), THF: CH₃CN (0.6 mL: 0.4 mL), 35 ℃, 12 h.

  下载: 全尺寸图片 幻灯片
  

  Scheme 3  Suggested catalytic cycle.

  下载: 全尺寸图片 幻灯片

  Table 1.  Optimization of reaction conditions of nickel-catalyzed reductive coupling reaction of monofluoroalkyl triflates with alkyl carboxylic acids. ^a

  下载: 导出CSV
•