引用本文:
Cheng Lu ZHANG, Xiao Lei ZHU, Ying Ge MA, Li Wei ZOU. First Total Synthesis of 12-Hydroxy-13-methylpodocarpa-9, 11, 13-trien-3-one[J]. Chinese Chemical Letters,
2006, 17(2): 163-164.
Citation: Cheng Lu ZHANG, Xiao Lei ZHU, Ying Ge MA, Li Wei ZOU. First Total Synthesis of 12-Hydroxy-13-methylpodocarpa-9, 11, 13-trien-3-one[J]. Chinese Chemical Letters, 2006, 17(2): 163-164.
Citation: Cheng Lu ZHANG, Xiao Lei ZHU, Ying Ge MA, Li Wei ZOU. First Total Synthesis of 12-Hydroxy-13-methylpodocarpa-9, 11, 13-trien-3-one[J]. Chinese Chemical Letters, 2006, 17(2): 163-164.
First Total Synthesis of 12-Hydroxy-13-methylpodocarpa-9, 11, 13-trien-3-one
摘要:
A first facile total synthesis of 12-hydroxy-13-methylpodocarpa-9, 11, 13-trien-3-one 9 was accomplished via a strategy of AC→ABC. In the synthetic process, compound 5 was synthesized through Reimer-Teimann reaction, followed by methylation, reduction, dehydration, addition to ethylene epoxide and chlorination. The target compound 9 was finally obtained through the condensation of Grignard reagent of compound 5 with 6, followed by intramolecular cyclization, reduction and demethylation.
English
First Total Synthesis of 12-Hydroxy-13-methylpodocarpa-9, 11, 13-trien-3-one
Abstract:
A first facile total synthesis of 12-hydroxy-13-methylpodocarpa-9, 11, 13-trien-3-one 9 was accomplished via a strategy of AC→ABC. In the synthetic process, compound 5 was synthesized through Reimer-Teimann reaction, followed by methylation, reduction, dehydration, addition to ethylene epoxide and chlorination. The target compound 9 was finally obtained through the condensation of Grignard reagent of compound 5 with 6, followed by intramolecular cyclization, reduction and demethylation.
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