摘要: Three new vortioxexine (VOT) salts with salicylic acid (SA), 5-fluorouracil (FU) and (p-nitrophenyl)-acetic acid (PA) have been synthesized and characterized in detail. In VOT-SA(1:1), the protonated VOT and deprotonated salicylic anion form a tetrameric unit with the R₄⁴ (12) synthon via N(1)-H(1)…O(1)^a (a:x-1, y, z) and N(1)-H(2)…O(2)^b (b:-x, -y, -z+1) hydrogen bonds. However, in VOT-FU(1:2), the protonated VOT and deprotonated 5-fluorouracil anion feature an R₄⁴ (16) ring motif via N(1)-H(1)…O(2)^c (c:-x+1, -y+1, -z+1) and N(1)-H(2)…O(1)^d (d:x, y-1, z) hydrogen bonds. The neutral FU extends the R₄⁴ (16) ring to form a two-dimensional structure through R₂²(8) N-H…O and N(6)-H(4)…N(4)^e (e:-x+1, y-1/2, -z+1/2) hydrogen bonds. In VOT-PA(1:1), PA molecules are linked through N(1)-H(1)…O(1)^f (f:-x+1, y+1/2, -z+1) and N(1)-H(2)…O(2), which forms a right-handed helical structure. Furthermore, components of the crystalline phase have also been investigated in terms of their corresponding Hirshfeld surface, and the salification improves the equilibrium solubilities and dissolution rates of VOT in three salts at 25℃ in water.