An improved synthesis of (lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane

Dong-Feng Zhang Peng Li Zi-Yun Lin Hai-Hong Huang

Citation:  Dong-Feng Zhang, Peng Li, Zi-Yun Lin, Hai-Hong Huang. An improved synthesis of (lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane[J]. Chinese Chemical Letters, 2014, 25(3): 479-481. doi: 10.1016/j.cclet.2013.12.006 shu

An improved synthesis of (lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane

    通讯作者: Hai-Hong Huang,
摘要: An improved and efficient method for synthesis of (lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane (1) from trans-4-hydroxy-L-proline was developed. Using benzyloxycarbonyl (Cbz) as protection group of amine, the reactions were inmild conditions, and the title compound 1 was accomplished in six steps in overall yield of 70%.

English

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  • 发布日期:  2013-12-07
  • 收稿日期:  2013-09-04
  • 网络出版日期:  2013-11-27
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