Synthesis and antibacterial activity of ethyl 2-amino-6-methyl-5-oxo-4-aryl-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylate

Sakineh Asghari Samaneh Ramezani Mojtaba Mohseni

Citation:  Sakineh Asghari, Samaneh Ramezani, Mojtaba Mohseni. Synthesis and antibacterial activity of ethyl 2-amino-6-methyl-5-oxo-4-aryl-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylate[J]. Chinese Chemical Letters, 2014, 25(3): 431-434. doi: 10.1016/j.cclet.2013.12.010 shu

Synthesis and antibacterial activity of ethyl 2-amino-6-methyl-5-oxo-4-aryl-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylate

    通讯作者: Sakineh Asghari,
摘要: The three-component reaction of 4-hydroxy-1-methyl-2(1H)-quinolinone, aromatic aldehydes and ethyl cyanoacetate was carried out in the presence of a catalytic amount of 4-dimethyl aminopyridine (DMAP) in aqueous ethanol. The reactions result in the formation of pyranoquinoline derivatives in excellent yields. Antibacterial activity has been evaluated against Gram positive and Gram negative bacteria for some of the synthesized compounds. The results indicated that these compounds are moderately effective against bacterial growth and their effectiveness is highest against Pseudomonas aeruginosa.

English

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  • 发布日期:  2013-12-08
  • 收稿日期:  2013-08-13
  • 网络出版日期:  2013-11-26
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