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An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents

Sangaraiah Nagarajan ,  Poovan Shanmugavelan ,  Murugan Sathishkumar ,  Ramasamy Selvi ,  Alagusundaram Ponnuswamy ,  Hariharan Harikrishnan ,  Vellasamy Shanmugaiah

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Citation:  Sangaraiah Nagarajan, Poovan Shanmugavelan, Murugan Sathishkumar, Ramasamy Selvi, Alagusundaram Ponnuswamy, Hariharan Harikrishnan, Vellasamy Shanmugaiah. An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents[J]. Chinese Chemical Letters, 2014, 25(3): 419-422. doi: 10.1016/j.cclet.2013.12.017 shu

An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents

    • 通讯作者: Alagusundaram Ponnuswamy,
    Vellasamy Shanmugaiah,
摘要: An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz. water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.

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  • 发布日期:  2013-12-24
  • 收稿日期:  2013-09-11
  • 网络出版日期:  2013-12-10
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