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Reversible photoswitching aggregation and dissolution of spiropyranfunctionalized copolymer and light-responsive FRET process

Lei-Xiao Yu ,  Yang Liu ,  Si-Chong Chen ,  Yue Guan ,  Yu-Zhong Wang

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Citation:  Lei-Xiao Yu, Yang Liu, Si-Chong Chen, Yue Guan, Yu-Zhong Wang. Reversible photoswitching aggregation and dissolution of spiropyranfunctionalized copolymer and light-responsive FRET process[J]. Chinese Chemical Letters, 2014, 25(3): 389-396. doi: 10.1016/j.cclet.2013.12.014 shu

Reversible photoswitching aggregation and dissolution of spiropyranfunctionalized copolymer and light-responsive FRET process

    • 通讯作者: Si-Chong Chen,
    Yu-Zhong Wang,
  • 基金项目:

    Innovative Research Team in University of Ministry of Education of China (No. IRT1026). (No. IRT1026)

摘要: Well-defined, reversibly light-responsive amphiphilic diblock copolymer grafted with spiropyran, was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. The copolymer self-assembles into polymeric micelles in water and exhibits reversible dissolution and re-aggregation characteristics upon ultraviolet (UV) and visible (Vis)-light irradiation. The fluorescence response of spiropyran immobilized onto the copolymer was light switchable. When nitrobenzoxadiazolyl derivative (NBD) dyes are encapsulated into the core of the micelles, a reversible, light-responsive, dual-color fluorescence resonance energy transfer (FRET) system is constructed and processed, which is well regulated by alternatively UV/vis irradiation. We anticipate these photoswitchable and FRET lighting up nanoparticles will be useful in drug delivery and cell imaging or tracking synchronously.

English

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  • 发布日期:  2013-12-24
  • 收稿日期:  2013-11-11
  • 网络出版日期:  2013-12-06
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