引用本文:
Min Zhu, Li Li, Jiang Ying Tong, Hui Zhang. An effective method for the preparation of chlorolactones[J]. Chinese Chemical Letters,
2011, 22(4): 431-434.
doi:
10.1016/j.cclet.2010.11.014
Citation: Min Zhu, Li Li, Jiang Ying Tong, Hui Zhang. An effective method for the preparation of chlorolactones[J]. Chinese Chemical Letters, 2011, 22(4): 431-434. doi: 10.1016/j.cclet.2010.11.014
Citation: Min Zhu, Li Li, Jiang Ying Tong, Hui Zhang. An effective method for the preparation of chlorolactones[J]. Chinese Chemical Letters, 2011, 22(4): 431-434. doi: 10.1016/j.cclet.2010.11.014
An effective method for the preparation of chlorolactones
摘要:
The effective chlorolactonization of alkenoic acids with (diacetoxyiodo)benzene and lithium chloride under mild conditions have been studied. Experiments show that various 4-pentenoic acids react with (diacetoxyiodo)benzene and lithium chloride fluently in CH3OH at room temperature, obtaining five-membered chlorolactones in good yields in short times. Other alkenoic acids, such as 3-butenoic acid and trans 3-hexenoic acid give some more complicated results, and 4-pentynoic acid provides a chloroenol lactone with Z configuration in 40% of yield.
English
An effective method for the preparation of chlorolactones
Abstract:
The effective chlorolactonization of alkenoic acids with (diacetoxyiodo)benzene and lithium chloride under mild conditions have been studied. Experiments show that various 4-pentenoic acids react with (diacetoxyiodo)benzene and lithium chloride fluently in CH3OH at room temperature, obtaining five-membered chlorolactones in good yields in short times. Other alkenoic acids, such as 3-butenoic acid and trans 3-hexenoic acid give some more complicated results, and 4-pentynoic acid provides a chloroenol lactone with Z configuration in 40% of yield.
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Key words:
- Chlorolactone
- / (Diacetoxyiodo)benzene
- / Alkenoic acid
- / Preparation
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