引用本文:
Xu Qin Li. The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy[J]. Chinese Chemical Letters,
2009, 20(10): 1201-1202.
doi:
10.1016/j.cclet.2009.05.001
Citation: Xu Qin Li. The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy[J]. Chinese Chemical Letters, 2009, 20(10): 1201-1202. doi: 10.1016/j.cclet.2009.05.001
Citation: Xu Qin Li. The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy[J]. Chinese Chemical Letters, 2009, 20(10): 1201-1202. doi: 10.1016/j.cclet.2009.05.001
The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy
摘要:
Quinazolinediones are particularly attractive pharmacophores because of their wide range of bioactivities.A convenient synthetic pathway to three-substituted quinazoline-2,4-dione derivatives was developed from substituted anthranilamide via carbonylation with Boc anhydride and then cyclization in the presence of the base sodium methoxide.Good to excellent yields have been achieved.
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关键词:
- Quinazolinediones
- / Carbonylation
- / Cyclization
- / Boc strategy
English
The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy
Abstract:
Quinazolinediones are particularly attractive pharmacophores because of their wide range of bioactivities.A convenient synthetic pathway to three-substituted quinazoline-2,4-dione derivatives was developed from substituted anthranilamide via carbonylation with Boc anhydride and then cyclization in the presence of the base sodium methoxide.Good to excellent yields have been achieved.
-
Key words:
- Quinazolinediones
- / Carbonylation
- / Cyclization
- / Boc strategy
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